What is Better, Profhilo or Polynucleotides?

By Mary Basiadima, 3 March 2025

When it comes to non-surgical skin rejuvenation, injectables like and are increasingly popular. Both treatments aim to skin quality, hydration, and elasticity, but they work in different ways. Choosing between them depends on your specific skin concerns and what kind of results you’re looking for. So here we examine what is better, Profhilo or Polynucleotides?

What is Profhilo?

Profhilo is an injectable skin booster that contains one of the highest concentrations of available. Unlike dermal fillers, which add volume and structure, spreads evenly under the skin, delivering deep hydration and stimulating collagen and elastin production. The result is smoother, firmer, and plumper skin with a natural radiance.

This treatment is particularly effective for skin laxity, fine lines, and dullness. It’s commonly used on the face, neck, and décolletage, as well as other areas prone to loss of elasticity, such as the hands. The effects are visible quite quickly, usually within a week or two, making it an ideal choice for those looking for a noticeable improvement with minimal downtime.

What are Polynucleotides?

Polynucleotides are a relatively new but highly promising treatment in the world of regenerative aesthetics. from purified Salmon DNA, polynucleotides work by stimulating fibroblasts—the cells responsible for and elastin production. Instead of simply hydrating the skin, they encourage deep tissue repair, improving skin texture, elasticity, and overall resilience.

This treatment is particularly beneficial for those with more advanced signs of ageing, , or conditions such as . Unlike Profhilo, which delivers instant hydration, polynucleotides work gradually, with the best results appearing over the course of several weeks to months as the skin regenerates from within.

How Do They Compare?

While both treatments aim to improve skin quality, they do so in different ways. Profhilo is all about hydration and , making it perfect for those who want a quick glow and firmer-looking skin. Polynucleotides, on the other hand, focus on cell repair and regeneration, making them a better option for those dealing with or inflamed skin.

Profhilo delivers results quite quickly, with most people noticing an improvement in their skin’s texture and radiance within a few weeks. Polynucleotides take longer to work, but the benefits are deeper and longer-lasting, as they promote actual skin healing rather than just boosting moisture levels.

Which One is Right for You?

The choice between Profhilo and depends on your individual skin concerns. If your main goal is to achieve deep hydration, a fresh glow, and firmer skin, Profhilo is an excellent choice. It’s particularly well-suited to people in their late 20s to 40s who are starting to notice the first signs of ageing.

For those looking for more intensive skin repair, improved elasticity, or help with issues like acne scars, under the eyes, or inflammation, polynucleotides offer a more regenerative approach. They are particularly effective for those with more mature skin or specific concerns that go beyond hydration.

Can You Combine Profhilo and Polynucleotides?

Yes, our practitioners combining both treatments for a comprehensive skin rejuvenation approach. Polynucleotides help to repair and strengthen the skin, while Profhilo provides hydration and glow. Some patients start with polynucleotides to rebuild their skin’s foundation and then follow up with Profhilo for added hydration and firmness.

What is Better, Profhilo or Polynucleotides?

Both and polynucleotides are excellent treatments, but they serve different purposes. If you’re looking for hydration, skin tightening, and an overall glow, Profhilo is the better choice. If your skin needs repair, deep regeneration, and collagen stimulation, polynucleotides may be more beneficial.

For the best results, consult with our experienced practitioners who can assess your skin’s condition and recommend the most suitable option. Whether you choose one or combine both, these treatments offer a subtle yet highly effective way to rejuvenate your skin without the need for invasive procedures.

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Polynucleotides and Profhilo are both injectable skin treatments designed to improve skin quality, but they work in very different ways. Profhilo is a hyaluronic acid-based skin booster that deeply hydrates the skin while stimulating collagen and elastin production. It spreads evenly under the skin, giving an overall plumping and effect, making it ideal for tackling dullness, fine lines, and skin laxity.

Polynucleotides, on the other hand, are derived from salmon DNA and work by stimulating fibroblasts and promoting deep skin . Instead of just hydrating the skin like Profhilo, polynucleotides repair and rebuild skin at a cellular level, improving elasticity, reducing inflammation, and even helping with scarring and pigmentation.

The key difference lies in their approach: Profhilo provides an instant hydration boost for fresher, firmer skin, while polynucleotides work over time to repair and strengthen the skin from within. Those looking for immediate radiance might prefer Profhilo, while those seeking long-term skin may more from polynucleotides.

Profhilo is one of the most well-known skin boosters on the market, but whether something is "better" depends on the results you’re looking for. While Profhilo excels at hydrating, smoothing, and improving skin laxity, other may be more effective for certain concerns.

For deeper skin repair and collagen stimulation, polynucleotides can be a superior option, for individuals with thin, fragile, or scarred skin.

For those looking for a more effect, or (High-Intensity Focused Ultrasound) may be preferable, as they work on tightening the skin while stimulating collagen at a deeper level.

Ultimately, the best treatment depends on your skin’s needs. If hydration and glow are the priority, Profhilo remains an excellent choice. If you want more targeted regeneration, firmness, or lifting, other treatments may offer better results.

Yes, polynucleotides have been clinically proven to repair and rejuvenate the skin by stimulating collagen production, increasing elasticity, and improving skin health. Unlike traditional skin boosters that simply hydrate, polynucleotides regenerate tissue, reduce inflammation, and restore damaged skin, making them particularly effective for concerns like fine lines, acne scar removal, rosacea, and under-eye rejuvenation.

Since polynucleotides work by stimulating the skin’s natural repair process, results are not immediate. Most people notice gradual improvements over several weeks, with the best results visible after a few months. However, because they stimulate collagen and cell renewal, the effects are longer-lasting to many hyaluronic acid-based treatments.

Our aesthetic practitioners are now incorporating polynucleotides into skin rejuvenation protocols because they offer more than just hydration—they actually improve skin structure and function. For those looking for a treatment that long-term skin health benefits rather than just a temporary glow, polynucleotides are a highly effective choice.

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